Week 05

Scientific Hypotesis

Ultra-Fast Regeneration Process

How to become inmortal

Explanation:

Some researchers in Mexico are already studying some fish from the species Astyanax Mexicanus to understand why some animal regenerate tissue but others can´t, like the Salamander for example, who can regenerate its tail, even with its spinal cord and nerves. Or the Axolotl, which is another kind of salamander, which can regenerate almost any part of its body. In some experiments, researchers have removed a limb from the Axolotl and figure out that it regrows almost perfectly. Or the opposite way for the Starfish, who can regenerate its whole body just from one arm, doing the regeneration process in a reverse way, by saving nutrients in its body until it regrows a new mouth.

Considering this, and taking into account the dogma of basic biology, RNA transfers information or recipes from DNA to ribosomes to produce different proteins and that some of these proteins even help in the process of regeneration of the skin, organs, wounds, and cells dead, is there any way to improve this process of transcription/translation in the cells, without accelerating their growth so that they don´t become carcinogenic, so that we can regenerate ourselves in a much faster and continuous way, and stay forever young and healthy?

https://ambystoma.uky.edu/index.php

https://www.theguardian.com/technology/2018/nov/25/five-animals-that-can-regenerate-salamander-starfish 


Hypothesis:

By accelerating the transcription/translation process with RNA, we are going to be able to accelerate the regeneration process in our cells and heal much faster, to the speed that we almost become immortal.

Methodology:

  1. Look for some species, bacteria or animals that have a faster regeneration process (Lizards maybe)
  2. Identify the section of the DNA that helps regeneration and isolate it to compare it to the human one to see if there´s something in the RNA information process that works differently.
  3. Use non modified human genes cell as a Negative Control and the Other species cell (faster regeneration) as a positive control. Salamander is a possibility.
  4. Try to chemical accelerate the process in human genes by improving the "travel roads" of RNA to the Ribosomes, maybe by adding some enzymes or modifying the friction generated in that path to make it move more fluently.
  5. Try to add these genes to an organism that´s similar to the humans with Crispr Cas9 and evaluate its regeneration process (check compatibility).
  6. Test the regeneration process in the selected animal.

  7. Apply the process that worked in other parts of genes related to regeneration (blood cells, skin, hair, bones, organs, etc).
  8. Test the possibilities for gene transfer between these species and humans.
  9. Try a control experiment with humans.

  10. Take the idea to hospitals where they threat wounded soldiers or burned children. Nuria commented that there´s already something called Tissue engineering with IPSc (induced pluripotent stem cells), with which they have been able to create stem cells from old cells without needing an embryo.
Voltio

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